Related Experiment Video
Updated: Feb 11, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
Published on: August 28, 2014
[Study of vascularization of hydroxyapatite/tricalcium phosphate biomaterials implanted in mice during
Abstract:
This study aims to explore the vascularization of hydroxyapatite/tricalcium phosphate(HA/TCP)biomaterials implanted in mice during osteoinduction. The HA/TCP biomaterials were implanted in muscle of mice, and2, 4, 6, 8, 10 and 12 weeks after the implantation, the materials were harvested to prepare serial sections and hematoxylineosin(HE) staining. The process of vascularization was dynamically described, and the area percentage of neovascularization was quantitatively analyzed. The results showed that neovascularization formation was a continuous and dynamic process. The neovascularization appeared largely in the first two weeks, with a rising trend in week 4,reached peak in week 6, and gradually reduced in week 8. The results provide ideas for improving the success rate of bone tissue engineering, and indicate the mechanism of osteoinduction.
Related Concept Videos
Phosphate Buffer
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
Imaging Studies VII: Vascular Imaging
Seedless Vascular Plants
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily...
Vascular Spasm
Overview of the Vascular System

