[Present status and prospects of injectable hydrogels for treatment of myocardial infarction]

Area of Science:

• Biomaterials science
• Cardiovascular medicine
• Regenerative medicine

Background:

• Myocardial infarction (MI) survivors frequently develop heart failure from post-infarct ventricular remodeling.
• Existing treatments inadequately suppress ventricular remodeling, increasing heart failure incidence.
• Coronary heart disease is now the primary cause of heart failure in China.

Purpose of the Study:

• To review the principles, current status, mechanisms, and future prospects of injectable hydrogel therapies for myocardial infarction (MI).
• To highlight the urgent need for effective treatments to prevent post-infarct ventricular remodeling.

Main Methods:

• Literature review of recent advancements in injectable hydrogel therapies for MI.
• Discussion of the underlying mechanisms of hydrogel action in the context of cardiac repair.
• Analysis of the current state and future potential of this therapeutic strategy.

Main Results:

• Injectable hydrogels represent a promising new strategy for treating MI.
• These hydrogels can be delivered via intramyocardial injection.
• Recent progress indicates significant potential for preventing adverse ventricular remodeling.

Conclusions:

• Injectable hydrogel therapy is an emerging and effective approach for managing myocardial infarction (MI).
• Further research into hydrogel mechanisms and clinical application is warranted.
• This strategy holds significant promise for preventing heart failure post-MI.