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Updated: Feb 11, 2026

Spatial Separation of Molecular Conformers and Clusters
Published on: January 9, 2014
Minimising conformational bias in fluoroprolines through vicinal difluorination
Gert-Jan Hofman1, Emile Ottoy, Mark E Light
1Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK. bruno.linclau@soton.ac.uk.
Abstract:
Monofluorination at the proline 4-position results in conformational effects, which is exploited for a range of applications. However, this conformational distortion is a hindrance when the natural proline conformation is important. Here we introduce (3S,4R)-3,4-difluoroproline, in which the individual fluorine atoms instil opposite conformational effects, as a suitable probe for fluorine NMR studies.
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