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Techniques for Imaging Ca2+ Signaling in Human Sperm
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[Outer dense fiber 2 and sperm function: Progress in studies].

Bin Luo1, Zi-Li Lü1

  • 1Center of Reproductive Medicine, The Second Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610041, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|May 3, 2018
PubMed
Summary
This summary is machine-generated.

Outer dense fiber protein 2 (ODF2) abnormalities are linked to male infertility, specifically low sperm motility. This review explores ODF2

Keywords:
centrosomefertilization failuremicrotubulesperm motilityouter dense fiber 2 protein

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Area of Science:

  • Reproductive Biology
  • Molecular Cell Biology
  • Sperm Biology

Background:

  • Male infertility is often caused by oligoasthenozoospermia or teratozoospermia, characterized by low sperm count, motility, or abnormal morphology.
  • Abnormalities in sperm tail structure and function are primary causes of reduced sperm motility.
  • Outer dense fiber protein 2 (ODF2) is crucial for maintaining sperm tail cytoskeleton and centrosome integrity, and its dysfunction is associated with asthenospermia.

Purpose of the Study:

  • To review the known functions of Outer dense fiber protein 2 (ODF2).
  • To explore the multifaceted nature of ODF2, recognizing it as more than a single structural protein.
  • To establish a foundation for future research into the role of ODF2 in fertilization.

Main Methods:

  • Literature review of existing studies on ODF2.
  • Analysis of ODF2's structural components and functional roles.
  • Synthesis of information regarding ODF2's involvement in sperm and embryonic development.

Main Results:

  • ODF2 is implicated in maintaining sperm tail structure and centrosome function.
  • ODF2 comprises multiple related proteins and splice variants.
  • ODF2 plays a role in ciliogenesis and sperm capacitation.

Conclusions:

  • ODF2's complex nature and diverse functions highlight its significance in male reproductive health.
  • Further investigation into ODF2 is warranted to fully understand its impact on fertilization.
  • ODF2 represents a potential target for addressing male infertility associated with sperm motility defects.