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Two case reports of zoledronic acid-induced uveitis
T Kennedy1, P W Sellar2, D Vaideanu-Collins3
1Newcastle University.
Age and Ageing
|May 3, 2018
Summary
Zoledronic acid, a bisphosphonate for osteoporosis, can cause acute anterior uveitis. Patients experiencing eye pain or blurred vision post-treatment should seek immediate medical attention.
Area of Science:
- Ophthalmology
- Rheumatology
- Pharmacology
Background:
- Zoledronic acid (zoledronate) is a bisphosphonate commonly prescribed for post-menopausal osteoporosis.
- Its administration is known to be associated with an acute phase reaction.
Observation:
- Two cases of anterior uveitis following initial zoledronate administration are presented.
- Symptoms included eye pain, decreased visual acuity, and in one case, vomiting, occurring approximately 24 hours post-infusion.
Findings:
- Both patients were diagnosed with anterior uveitis.
- Treatment varied, including sub-conjunctival corticosteroid injections and topical steroids, with one patient requiring cataract surgery.
Implications:
- Patients receiving zoledronate should be informed about potential ocular side effects.
- Prompt reporting and management of symptoms like red, painful eyes or blurred vision are crucial to prevent vision loss.
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