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Neutral Theory in Cancer Cell Population Genetics
Atsushi Niida1, Watal M Iwasaki2, Hideki Innan2
1The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Abstract:
Kimura's neutral theory provides the whole theoretical basis of the behavior of mutations in a Wright-Fisher population. We here discuss how it can be applied to a cancer cell population, in which there is an increasing interest in genetic variation within a tumor. We explain a couple of fundamental differences between cancer cell populations and asexual organismal populations. Once these differences are taken into account, a number of powerful theoretical tools developed for a Wright-Fisher population could be readily contribute to our deeper understanding of the evolutionary dynamics of cancer cell population.
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