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Updated: Feb 11, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Impact of left atrial appendage closure on cardiac functional and structural remodeling: A difference-in-difference

Quang Tan Phan1,2, Seung-Yong Shin3, Ik-Sung Cho3

  • 1Cardiovascular Center, Chung-Ang University Hospital, Seoul, South Korea. quangft@gmail.com.

Cardiology Journal
|May 3, 2018
PubMed

Insights

Left atrial appendage closure (LAAC) in nonvalvular atrial fibrillation (NVAF) patients significantly increases left atrial size and filling pressures. Further research is needed to understand the clinical implications of these cardiac remodeling changes post-LAAC.

Area of Science:

  • Cardiology
  • Medical Devices
  • Cardiac Electrophysiology

Background:

  • Limited data exist on the impact of Left Atrial Appendage Closure (LAAC) on cardiac remodeling in patients with Nonvalvular Atrial Fibrillation (NVAF).
  • Existing research primarily focuses on the safety and efficacy of LAAC, with less attention to its effects on cardiac structure and function.

Purpose of the Study:

  • To investigate the effects of LAAC on cardiac functional and structural remodeling in NVAF patients.
  • To compare cardiac remodeling changes between NVAF patients who underwent LAAC and a matched control group.

Main Methods:

  • A study included 47 NVAF patients undergoing LAAC (LAAC group) and 141 controls (non-LAAC group).
  • Propensity score matching was used to form the control group.
  • Difference-in-difference analysis assessed cardiac remodeling at baseline and follow-up.

Main Results:

  • The LAAC group showed significant increases in left atrial (LA) dimension, volume, and volume index compared to the non-LAAC group.
  • Significant increases in E and E/e' ratio were observed in the LAAC group, indicating elevated LV filling pressures.
  • Left ventricular (LV) ejection fraction and fractional shortening decreased slightly in the LAAC group, though not statistically significant.

Conclusions:

  • LAAC in NVAF patients leads to significant increases in LA size and LV filling pressures.
  • These observed changes in cardiac remodeling following LAAC warrant further investigation for their clinical significance.
  • Future studies should explore the long-term clinical implications of LAAC-induced cardiac remodeling.
Abstract

Keywords:
atrial fibrillationcardiac remodelingdiastolic functiondifference-in-difference analysisleft atrial appendage closurestroke preventionsystolic function

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