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Recent Progress in Polymer Research to Tackle Infections and Antimicrobial Resistance

Mohini Mohan Konai1, Brinta Bhattacharjee1, Sreyan Ghosh1

  • 1Antimicrobial Research Laboratory, New Chemistry Unit , Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064 , Karnataka , India.

Biomacromolecules
|May 3, 2018
PubMed

Insights

Novel polymer strategies combat drug-resistant microbes and biofilms. This review details antimicrobial polymers, hydrogels, and surfaces, highlighting their therapeutic potential against challenging infections.

Area of Science:

  • Biomaterials Science
  • Infectious Diseases
  • Polymer Chemistry

Background:

  • Emerging drug-resistant microbes and biofilms pose a significant global health threat, leading to difficult-to-treat infections.
  • Traditional treatments are becoming less effective, necessitating innovative approaches to combat microbial resistance.

Purpose of the Study:

  • To review and discuss recent advancements in polymer-based antimicrobial strategies for treating drug-resistant microbial infections.
  • To analyze the structure-activity relationships, antibiofilm efficacy, and in vivo performance of antimicrobial polymers.

Main Methods:

  • Review of literature on antimicrobial polymers inspired by antimicrobial peptides (AMPs).
  • Elaboration on antimicrobial hydrogels synthesized from antimicrobial polymers or loaded with biocides.
  • Discussion of strategies for engineering polymer-coated antimicrobial surfaces.

Main Results:

  • Antimicrobial polymers show promise as therapeutics, with structure-activity analyses guiding design.
  • Antimicrobial hydrogels and polymer-coated surfaces offer versatile platforms for infection control.
  • Demonstrated antibiofilm activity and in vivo efficacy of various polymer-based approaches.

Conclusions:

  • Polymer-based strategies, including antimicrobial polymers, hydrogels, and coated surfaces, represent a promising frontier in combating antimicrobial resistance.
  • Further research and development are crucial to overcome current challenges and expand the clinical application of these materials.
  • Addressing antimicrobial resistance requires continued innovation in material science and therapeutic design.

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