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Lenvatinib for the treatment of renal cell carcinoma

Giandomenico Roviello1, Silvia Paola Corona2, Giovanni Bozza1

  • 1a Division of Medical Oncology, Department of Onco-Hematology , IRCCS-CROB, Referral Cancer Center of Basilicata , Rionero, Vulture , Italy.

Expert Opinion on Investigational Drugs
|May 3, 2018
PubMed
Abstract

Insights

Lenvatinib combined with everolimus shows promise for advanced renal cell carcinoma (RCC) by targeting angiogenesis and mTOR signaling. Future research may explore adding immunotherapy to this combination for enhanced RCC treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Renal cell carcinoma (RCC) represents 2-3% of all solid tumors.
  • Vascular Endothelial Growth Factor (VEGF) receptor expression is a common feature in RCC.

Purpose of the Study:

  • To review available data on lenvatinib for advanced/metastatic renal cell carcinoma.
  • To summarize the efficacy of lenvatinib, particularly in combination with everolimus.

Main Methods:

  • Review of clinical and laboratory data on lenvatinib in RCC treatment.
  • Analysis of combination therapy including lenvatinib and everolimus.

Main Results:

  • Lenvatinib, a multi-kinase inhibitor, shows promising results in RCC treatment.
  • The combination of lenvatinib and everolimus demonstrates encouraging outcomes.

Conclusions:

  • Blocking angiogenesis and mTOR signaling pathways is a viable strategy for RCC.
  • Future studies should investigate combining lenvatinib, everolimus, and immunotherapy for advanced RCC.
Keywords:
FGFR1–4LenvatinibPDGFRαRETRenal cell carcinomaVEGFR1–3c-KIT

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