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Updated: Feb 11, 2026
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
1.2K
Radioembolization in Advanced Hepatocellular Carcinoma
Ahsun Riaz1, Robert Lewandowski1, Riad Salem1
1Ahsun Riaz, Robert Lewandowski, and Riad Salem, Northwestern University, Chicago IL.
Summary
This case study highlights advanced hepatocellular carcinoma in a 68-year-old man with a history of alcohol abuse. The patient presented with abdominal pain and was diagnosed with Barcelona Clinic for Liver Cancer stage C.
Area of Science:
- Hepatobiliary Malignancies
- Gastroenterology
- Oncology
Background:
- Hepatocellular carcinoma (HCC) is a primary liver cancer with significant global incidence.
- Early diagnosis and staging are critical for effective management of HCC.
- Portal vein thrombosis is a common complication in advanced HCC.
Purpose of the Study:
- To present a clinical case of advanced hepatocellular carcinoma.
- To illustrate diagnostic and management challenges in HCC.
- To provide context for applying research findings to clinical practice.
Main Methods:
- Case report of a 68-year-old male with vague abdominal pain.
- Diagnostic workup included laboratory tests (alpha-fetoprotein, liver function), imaging (MRI with contrast), and biopsy.
- Staging utilized the Barcelona Clinic for Liver Cancer (BCLC) classification.
Main Results:
- Patient presented with an Eastern Cooperative Oncology Group performance status of 1 and Child-Pugh A liver status.
- MRI revealed an infiltrative mass with extensive malignant portal vein thrombosis.
- Biopsy confirmed hepatocellular carcinoma; staging classified the patient as BCLC stage C.
Conclusions:
- The case demonstrates a complex presentation of advanced hepatocellular carcinoma.
- Management of BCLC stage C HCC requires specialized oncological and hepatobiliary expertise.
- Effective application of clinical trial data is crucial for optimizing patient care.
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