Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy
Elena Dalle Vedove1, Gabriella Costabile1, Olivia M Merkel1
1Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-Universität, München, 81377, Munich, Germany.
Abstract:
In order to overcome the main disadvantages of conventional cancer therapies, which prove to be inadequate because of their lack of selectivity, the development of targeted delivery systems is one of the main focuses in anticancer research. It is repeatedly shown that decorating the surface of nanocarriers with high-affinity targeting ligands, such as peptides or small molecules, is an effective way to selectively deliver therapeutics by enhancing their specific cellular uptake via the binding between a specific receptor and the nanosystems. Nowadays, the need of finding new potential biological targets with a high endocytic efficiency as well as a low tendency to mutate is urgent and, in this context, mannose and mannose-6-phosphate receptors appear promising to target anticancer drugs to cells where their expression is upregulated. Moreover, they open the path to encouraging applications in immune-based and gene therapies as well as in theragnostic purposes. In this work, the potential of mannose- and mannose-6-phosphate-targeted delivery systems in cancer therapy is discussed, emphasizing their broad application both in direct treatments against cancer cells with conventional chemotherapeutics or by gene therapy and also their encouraging capabilities in immunotherapy and diagnostics purposes.
Insights
Targeted cancer therapies using mannose and mannose-6-phosphate receptors enhance drug delivery. These nanocarrier systems show promise for direct cancer treatment, immunotherapy, and diagnostics.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Conventional cancer therapies lack selectivity, leading to inadequate treatment outcomes.
- Targeted delivery systems enhance therapeutic efficacy by improving selective cellular uptake.
- Identifying biological targets with high endocytic efficiency and low mutation rates is crucial for effective cancer drug delivery.
Purpose of the Study:
- To discuss the potential of mannose and mannose-6-phosphate receptors for targeted cancer therapy.
- To explore the application of these receptors in enhancing drug delivery and cellular uptake.
- To highlight the versatility of these targeting systems in various therapeutic and diagnostic approaches.
Main Methods:
- Decorating nanocarrier surfaces with high-affinity targeting ligands (mannose and mannose-6-phosphate).
- Utilizing specific receptor-ligand binding to enhance targeted cellular uptake of therapeutics.
- Reviewing existing literature and research on mannose- and mannose-6-phosphate-targeted delivery systems.
Main Results:
- Mannose and mannose-6-phosphate receptors demonstrate promise as targets for anticancer drug delivery.
- Targeted systems show enhanced specific cellular uptake via receptor-ligand interactions.
- These receptors facilitate applications in direct chemotherapy, gene therapy, immunotherapy, and theranostics.
Conclusions:
- Mannose- and mannose-6-phosphate-targeted delivery systems offer a promising strategy to overcome limitations of conventional cancer therapies.
- These systems enable selective delivery of anticancer drugs, improving treatment efficacy.
- Their potential extends to immunotherapy, gene therapy, and theranostic applications in oncology.
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:28Drug Therapy
Antianxiety Medications
01:25Control Systems: Applications
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
01:25Drug-Receptor Bonds
In...
01:29Drug-Receptor Interactions
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....