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Risk Factors of Nocturnal Enuresis in Children with Attention Deficit Hyperactivity Disorder
Habibolah Khazaie1, Farshid Eghbali1, Houshang Amirian1
1Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Insights
Attention deficit hyperactivity disorder (ADHD) is linked to a high prevalence of nocturnal enuresis (NE) in children. Risk factors include male sex, low parental education, neonatal sepsis, family history of NE, low birth weight, and C-section delivery.
Area of Science:
- Pediatrics
- Child Psychiatry
- Urology
Background:
- Attention deficit hyperactivity disorder (ADHD) negatively impacts the resolution of incontinence.
- Limited research exists on nocturnal enuresis (NE) risk factors in children with ADHD.
Purpose of the Study:
- To determine the prevalence of NE in children diagnosed with ADHD.
- To identify specific risk factors associated with NE in this population.
Main Methods:
- A cohort of 331 children aged 6-10 years with ADHD was studied.
- ADHD diagnoses were confirmed using DSM-IV-TR criteria.
- NE was defined as nighttime wetting (with or without daytime wetting) occurring at least twice weekly for 3+ months in children aged 5+ without anatomical abnormalities.
Main Results:
- The inattentional subtype of ADHD showed the highest NE prevalence (77.5%).
- Significant risk factors for NE included a history of familial enuresis, cesarean delivery, and neonatal sepsis.
- Lower birth weight and lower parental education levels were also associated with increased NE rates.
Conclusions:
- Children with ADHD exhibit a high prevalence of NE.
- Identified risk factors for NE in ADHD children include male sex, low parental education, neonatal sepsis, familial history of NE, low birth weight, and cesarean delivery.
- The inattentional ADHD subtype is particularly associated with NE.
Background:
Presence of attention deficit hyperactivity disorder (ADHD) has a negative effect on the resolution of incontinence; however, there are few studies which investigated the risk factors of nocturnal enuresis (NE) in patients with ADHD.
Aims:
This study was conducted to investigate the prevalence of NE and its risk factors in children with ADHD.
Methods:
331 children, aged 6 to 10 years, diagnosed as having ADHD were enrolled in this study. The diagnosis of ADHD was confirmed by an experienced child and adolescent psychiatrist according to DSM-IV-TR. NE was defined as nighttime wetting with or without daytime incontinence, at least twice a week over a period of 3 months or longer in children 5 years old and older without anatomical abnormalities. Details on demographic data, perinatal history, medical history and developmental history were collected from parents or medical records.
Results:
Most of the ADHD patients with inattentional subtype (77.5%) had NE, compared to 31.7% in the hyperactive/Impulsive subtype and 22.5% in the combined subtype (p<0.001, t=42.71). Among children with enuresis, there were significantly higher rates of history of familial enuresis (26% vs. 18 %, p<0.001, t=16.9), cesarean delivery (47% vs. 33%, p=0.019, t=5.84) and history of neonatal sepsis (16% vs. 7%, p=0.018, t=5.62) than non-NE children. Moreover, patients with NE had lower birth weight than non-NE patients (2.93(0.65) vs. 3.09 (0.46), p=0.026, t=2.51). Also, low parental education was associated with increase in the rate of NE.
Conclusion:
Children with ADHD have a high prevalence of NE. Male sex, low education level of parents, history of neonatal sepsis, positive family history of NE, low birth weight and caesarian delivery may be risk factors for NE in ADHD children. Most ADHD patients with inattentional subtype had NE.
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