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Consideration of methods for identifying mite allergens

Yubao Cui1, Qiong Wang1, Haoyuan Jia1

  • 1Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023 Jiangsu Province People's Republic of China.

Clinical and Translational Allergy
|May 3, 2018
PubMed

Insights

House dust mite allergens trigger allergies globally. This review details methods to identify these proteins, aiding in diagnosis and personalized treatments for allergic patients.

Area of Science:

  • Immunology
  • Allergology
  • Biochemistry

Background:

  • House dust mites (HDM) are significant sources of allergens.
  • HDM allergens, found in feces, body parts, and eggs, are major triggers of human allergies worldwide.
  • Accurate identification of these allergens is crucial for effective management.

Purpose of the Study:

  • To review and categorize current methods for identifying house dust mite allergens.
  • To discuss the strengths and weaknesses of various allergen identification techniques.
  • To highlight the need for novel discovery methods.

Main Methods:

  • Literature search (1995-2016) for allergen identification techniques.
  • Categorization of methods into discovery and confirmation phases.
  • Description of techniques including IgE-binding assays, protein isolation, and immune response assays.

Main Results:

  • Allergen identification involves distinct discovery and confirmation phases.
  • Discovery phase screens for IgE-binding proteins.
  • Confirmation phase purifies allergens and validates their immunogenicity.

Conclusions:

  • Current methods provide a framework for allergen identification.
  • A subset of proteins elicits responses in most allergic patients.
  • New discovery methods are essential for a comprehensive allergen panel and tailored therapies.
Keywords:
Allergen classificationAllergen identificationDust mite allergenMite allergenMite allergy

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