Related Experiment Video

Updated: Feb 11, 2026

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.1K

Regional myocardial motion in patients with mild cognitive impairment: a pilot study

Heng Ma1,2, Jun Yang1, Haizhu Xie1

  • 1Department of Radiology, Yuhuangding Hospital, Qingdao University School of Medicine, 20 E Yuhuangding Rd, Yantai, 264000, Shandong, China.

BMC Cardiovascular Disorders
|May 4, 2018
PubMed
Abstract

Insights

Individuals with mild cognitive impairment (MCI) exhibit altered heart muscle motion detected by cardiac MRI. These cardiac MRI findings may serve as early indicators for neurodegenerative diseases like Alzheimer's disease.

Area of Science:

  • Cardiology
  • Neurology
  • Radiology

Background:

  • Cardiovascular disease (CVD) is a known risk factor for cognitive impairment in the elderly.
  • Subclinical CVD manifestations are observed in patients with cognitive impairment.
  • This study investigated differences in cardiac MRI-derived myocardial motion between MCI patients and healthy controls.

Purpose of the Study:

  • To test the hypothesis that patients with mild cognitive impairment (MCI) exhibit distinct magnetic resonance imaging (MRI)-derived regional myocardial motion indices compared to healthy controls.
  • To explore the potential of cardiac MRI parameters as biomarkers for neurodegenerative disorders.

Main Methods:

  • Eleven MCI patients and 11 age-/sex-matched healthy controls underwent head and cardiac MRI.
  • Global cortical atrophy (GCA) was assessed from head MRI.
  • Cardiac MRI measured left ventricular ejection fraction (LVEF), regional strain, strain rate, displacement, and velocity.
  • Statistical comparison using t-tests was performed between groups.

Main Results:

  • MCI patients showed higher GCA scores (p=0.048) but similar LVEF compared to controls.
  • Significantly lower peak radial strain, peak diastolic radial and circumferential strain rates, peak systolic radial displacement, and peak diastolic radial and circumferential velocities were observed in MCI patients (all p<0.005).

Conclusions:

  • Cardiac MRI-derived regional myocardial motion indices differ significantly between MCI patients and healthy controls.
  • These quantitative imaging biomarkers hold potential for identifying individuals at risk for neurodegenerative diseases like Alzheimer's disease.
Keywords:
Cardiac MRIMild cognitive impairmentRegional myocardial motion

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.1K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.8K

Related Concept Videos

Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Pilot and Numeric Relaying01:21

Pilot and Numeric Relaying

Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
496
IR Frequency Region: Fingerprint Region01:03

IR Frequency Region: Fingerprint Region

IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
2.0K
Equation of Motion: General Plane motion01:22

Equation of Motion: General Plane motion

In the context of a rigid body's movement within a general plane, it is important to understand that this motion is typically triggered by external forces or couple moments exerted onto it. This principle can be explained through Newton's second law, which stipulates the translational motion of the body's center of mass along each axis.
Moreover, the body's center of mass experiences a rotational effect as a result of these couple moments. This rotation can be articulated as the...
590
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
162
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.9K