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Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis.
Shanhu Qiu1, Xue Cai1, Han Yin1
1Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, People's Republic of China.
Exercise training, especially aerobic and combined routines, improves endothelial function in type 2 diabetes patients. However, the benefits are less pronounced compared to non-diabetics.
Area of Science:
- Cardiovascular Health
- Metabolic Disorders
- Exercise Physiology
Background:
- Type 2 diabetes is linked to poor endothelial function, impacting cardiovascular health.
- Exercise training is a key management strategy, but its specific effects on endothelial function in this population require clarification.
Purpose of the Study:
- To meta-analyze the association between exercise training and endothelial function in type 2 diabetes patients.
- To investigate the impact of different exercise types on endothelial function.
Main Methods:
- Searched databases up to January 2018 for studies of exercise interventions (≥8 weeks) assessing endothelial function via flow-mediated dilation (FMD).
- Included studies on type 2 diabetes patients or comparisons between diabetics and non-diabetics.
- Utilized random-effects models for data pooling.
Main Results:
- Exercise training significantly improved FMD by 1.77% in type 2 diabetes patients.
- Aerobic and combined aerobic/resistance exercise showed significant improvements (1.21% and 2.49% FMD increase, respectively).
- Improvements in FMD were smaller in type 2 diabetes patients compared to non-diabetics.
Conclusions:
- Aerobic and combined exercise effectively enhance endothelial function in type 2 diabetes.
- The positive effects of exercise on endothelial function are attenuated in individuals with type 2 diabetes compared to their non-diabetic counterparts.
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