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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Invasive Methicillin-Resistant Staphylococcus aureus USA500 Strains from the U.S. Emerging Infections Program

M B Frisch1, S Castillo-Ramírez2, R A Petit1

  • 1Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Msphere
|May 4, 2018
PubMed
Summary
This summary is machine-generated.

USA500 methicillin-resistant Staphylococcus aureus (MRSA) strains are genetically distinct CC8 subtypes. This study clarifies USA500 classification and reveals geographic and genetic variations, including antibiotic resistance differences.

Keywords:
IS256MRSAUSA300adenosinedrug resistanceevolution

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Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • USA500 are clonal complex 8 (CC8) Staphylococcus aureus strains, related to USA300.
  • USA500 are the third most common MRSA in U.S. surveillance but are understudied.
  • These strains cause a significant disease burden.

Purpose of the Study:

  • To genetically characterize USA500 MRSA strains.
  • To understand the evolutionary relationships within USA500.
  • To refine the definition and classification of USA500 strains.

Main Methods:

  • Whole-genome sequencing of 539 USA500 MRSA isolates from U.S. sterile site infections (2005-2013).
  • Phylogenetic analysis to determine genetic relationships and population structure.
  • Identification of genetic markers, including insertion elements and gene mutations.

Main Results:

  • USA500 isolates formed three major clades (C1, C2, E1) with distinct geographic distributions (Northeast, South, West).
  • Clade C1 strains showed increased IS256 elements and higher antibiotic resistance.
  • Clades C1 and C2 shared an AdsA gene frameshift mutation.

Conclusions:

  • The term 'USA500' should encompass CC8 strains closely related to C1, C2, and E1, excluding USA300.
  • A genome-based phylogeny clarifies USA500 subclades and their geographic associations.
  • This work provides a framework for understanding CC8 adaptations driving MRSA virulence.