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A Melanoma Patient-Derived Xenograft Model
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FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts

Evan F Garner1, Adele P Williams1, Laura L Stafman1

  • 1Division of Pediatric Surgery, Department of Surgery, University of Alabama, Birmingham, Birmingham, AL, USA.

Scientific Reports
|May 4, 2018
PubMed

Insights

FTY720 (fingolimod) shows promise in treating Group 3 medulloblastoma. This drug decreased tumor cell growth, migration, and invasion in patient-derived xenografts, significantly reducing tumor size in vivo.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Group 3 medulloblastomas represent 28% of cases and have a poor prognosis.
  • FTY720 (fingolimod), an established immunosuppressant, exhibits anticancer properties in various cell lines.

Purpose of the Study:

  • To investigate the efficacy of FTY720 (fingolimod) in reducing the tumorigenicity of Group 3 medulloblastoma patient-derived xenografts (PDXs).

Main Methods:

  • Utilized three Group 3 medulloblastoma PDXs (D341, D384, D425).
  • Assessed PP2A expression and activation, cell viability, proliferation, migration, invasion, and cell cycle.
  • Evaluated in vivo tumor growth in a flank model using D425 PDX cells.

Main Results:

  • FTY720 activated PP2A, decreasing cell viability, proliferation, migration, and invasion in all three PDXs.
  • Induced G1 cell cycle arrest in medulloblastoma cells.
  • Significantly inhibited tumor growth in vivo in the D425 PDX flank model.

Conclusions:

  • FTY720 demonstrates significant antitumor effects against Group 3 medulloblastoma PDX cells in vitro and in vivo.
  • These findings support further investigation of FTY720 as a potential therapeutic agent for medulloblastoma.

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