Related Experiment Video
Updated: Feb 11, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
Published on: July 14, 2011
Comprehensive analysis of telomerase inhibition by gallotannin
Nikita Savelyev1, Polina Baykuzina2, Svetlana Dokudovskaya3
1Lomonosov Moscow State University, Department of Chemistry, and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, 119992, Russia.
Abstract:
Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound.
Related Concept Videos
Telomeres and Telomerase
Telomeres and Telomerase
Feedback Inhibition
Enzyme Inhibition
Inhibition of Cdk Activity
Qualitative Analysis
For instance, group IV...

