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Updated: Feb 11, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Diabetes mellitus and bone health: epidemiology, etiology and implications for fracture risk stratification
Rodrigo J Valderrábano1, Maria I Linares1
1University of Miami Miller School of Medicine, Dominion Tower 1400 NW 10th Ave, Ste. 805A, Miami, FL 33136 USA.
Abstract:
Skeletal fractures can result when there are co-morbid conditions that negatively impact bone strength. Fractures represent an important source of morbidity and mortality, especially in older populations. Diabetes mellitus is a metabolic disorder that has reached worldwide epidemic proportions and is increasingly being recognized as a risk factor for fracture. Type 1 and Type 2 diabetes have different effects on bone mineral density but share common pathways, which lead to bone fragility. In this review, we discuss the available data on diabetes and fractures, bone density and the clinical implications for fracture risk stratification in current practice.
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