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Decision-Making in Multiple Sclerosis Patients: A Systematic Review

Mireille Neuhaus1, Pasquale Calabrese2,3, Jean-Marie Annoni1,4

  • 1Unit of Neurology, University and Hospital of Fribourg, Fribourg, Switzerland.

Multiple Sclerosis International
|May 4, 2018
PubMed
Abstract

Insights

Multiple sclerosis (MS) patients often show impaired decision-making skills, affecting both quantitative and qualitative aspects. These deficits can occur independently of other cognitive changes, impacting daily life.

Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Multiple sclerosis (MS) is linked to cognitive and behavioral deficits.
  • Emerging research indicates MS impacts decision-making abilities.

Purpose of the Study:

  • To determine if MS patients' decision-making performance differs from controls.
  • To assess if decision-making alterations correlate with cognitive dysfunction and emotional changes.

Main Methods:

  • Systematic review of 12 studies from Pubmed/Medline.
  • Inclusion of studies comparing MS patients and healthy controls on validated decision-making tasks.
  • Analysis of quantitative (net scores) and qualitative (deliberation time, feedback learning) outcomes.

Main Results:

  • Decision-making impairment (quantitative and qualitative) observed in 64.7% of measurements in MS patients.
  • Impairment was consistent across decision-making tasks involving risk and ambiguity.
  • Fifty percent of cases showed correlation with other cognitive functions, particularly processing speed and attention.

Conclusions:

  • MS patients may exhibit decision-making impairments, irrespective of task type or other cognitive deficits.
  • These decision-making alterations are significant for daily functioning.
  • Addressing decision-making is crucial for comprehensive MS treatment strategies.

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