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Nanostructured surfaces for analysis of anticancer drug and cell diagnosis based on electrochemical and SERS tools

Waleed A El-Said1,2, Jinho Yoon1, Jeong-Woo Choi1

  • 11Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul, 04375 Republic of Korea.

Nano Convergence
|May 4, 2018
PubMed

Insights

New electrochemical cell chips and surface-enhanced Raman spectroscopy (SERS) offer fast, nondestructive methods for detecting anticancer drug effects and mechanisms, reducing drug discovery resources.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Pharmacology

Background:

  • Anticancer drug discovery is resource-intensive and time-consuming.
  • Need for rapid, sensitive, and nondestructive methods for evaluating drug efficacy and mechanisms.
  • Nanostructured surfaces enable advanced detection techniques.

Purpose of the Study:

  • To review electrochemical cell chips and SERS for anticancer drug evaluation.
  • To highlight their application in in vitro and in vivo studies.
  • To assess their potential in accelerating drug discovery.

Main Methods:

  • Review of research on nanostructure-based electrochemical cell chips.
  • Review of research on nanostructure-based surface-enhanced Raman spectroscopy (SERS).
  • Focus on in vitro and in vivo applications for drug monitoring.

Main Results:

  • Electrochemical cell chips effectively detect cell viability and cytotoxic effects at low concentrations.
  • SERS provides label-free, nondestructive monitoring of drug distribution, mechanism, and metabolism.
  • Both techniques demonstrate high capability in evaluating anticancer drug actions.

Conclusions:

  • Electrochemical cell chips and SERS are powerful tools for in vitro and in vivo anticancer drug assessment.
  • These nanostructure-based techniques significantly reduce time and resources in drug discovery.
  • Their application facilitates a deeper understanding of drug effects and action mechanisms at the cellular level.
Keywords:
Anticancer drugsCell-based chipDrug metabolismElectrochemistryRaman spectroscopySurface-enhanced Raman spectroscopyTumor investigation

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