Polysaccharide-Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to...

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Nanotechnology

Background:

• Polysaccharides are natural polymers composed of monosaccharides linked by glycosidic bonds.
• These carbohydrate-based materials offer biocompatibility and biodegradability for biomedical uses.

Purpose of the Study:

• To review four key polysaccharides: alginate, chitosan, hyaluronic acid, and dextran.
• To highlight their chemical modification, preparation, and fabrication techniques.
• To discuss preclinical and clinical applications in drug delivery and tissue engineering.

Main Methods:

• Review of chemical modification strategies for polysaccharides.
• Analysis of cargo fabrication techniques for polysaccharide-based systems.
• Summary of preclinical studies in disease treatment and tissue engineering.
• Evaluation of clinical translation and ongoing trials.

Main Results:

• Polysaccharides are extensively modified for tailored biomedical applications.
• Various fabrication techniques enable diverse polysaccharide-based drug delivery systems.
• Significant progress in preclinical applications for therapeutic and monitoring purposes.
• Emerging clinical trials demonstrate the translational potential of these biomaterials.

Conclusions:

• Polysaccharide-based materials are highly adaptable for biomedical needs.
• Advancements in nanotechnology and polymer chemistry accelerate clinical translation.
• Polysaccharide drug delivery systems show significant promise for future therapeutics.