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Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
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Practical consensus recommendations for tumor margins and breast conservative surgery.
R Sarin1, S P Somsekhar2, R Kumar3
1Department of Surgical Oncology, Apollo Indraprastha Hospital, New Delhi, India.
South Asian Journal of Cancer
|May 4, 2018
Summary
Survival rates for breast cancer patients are similar whether treated with mastectomy or breast-conserving therapy with radiotherapy. Positive margins increase local recurrence risk, but definitions lack consensus, complicating re-excision decisions.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Mastectomy and breast conservation therapy (BCT) with radiotherapy are standard breast cancer treatments.
- Positive surgical margins are linked to higher local recurrence rates in breast cancer.
- Current literature lacks a consensus on defining acceptable surgical margins after breast cancer surgery.
Purpose of the Study:
- To compare survival outcomes between mastectomy and BCT with radiotherapy for breast cancer patients.
- To highlight the clinical significance of positive margins in breast cancer local recurrence.
- To address the lack of consensus on acceptable margin definitions and its impact on clinical decision-making.
Main Methods:
- Comparative survival analysis of patients undergoing mastectomy versus BCT with radiotherapy.
- Review of literature to identify definitions of positive surgical margins in breast cancer.
- Analysis of the impact of margin status on local recurrence risk.
Main Results:
- No significant difference in survival was observed between patients treated with mastectomy or BCT plus radiotherapy.
- Positive margins were confirmed as a significant factor associated with an increased risk of local recurrence.
- A notable lack of consensus exists in the literature regarding the definition of acceptable surgical margins.
Conclusions:
- Mastectomy and BCT with radiotherapy offer comparable survival benefits for breast cancer patients.
- Clearer definitions of acceptable surgical margins are needed to guide re-excision decisions and optimize patient care.
- Standardizing margin assessment is crucial for improving local recurrence management in breast cancer treatment.
Keywords:
Acceptable marginextensive intraductal componentnodal metastasisoriginal sizere-excisionresectionMore Related Videos
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