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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Practical consensus recommendations on management of triple-negative metastatic breast cancer

R Rangarao1, B K Smruti2, K Singh3

  • 1Department of Medical Oncology, Max Hospital, New Delhi, India.

South Asian Journal of Cancer
|May 4, 2018
PubMed

Insights

Metastatic triple-negative breast cancer (mTNBC) presents limited treatment options due to therapy resistance. This consensus provides community oncologists with practical recommendations for new chemotherapeutic strategies in mTNBC management.

Area of Science:

  • Oncology
  • Medical Oncology
  • Breast Cancer Research

Background:

  • Metastatic triple-negative breast cancer (mTNBC) lacks targeted therapies, with limited options after standard treatment failure.
  • Patients with mTNBC often experience rapid relapse, highlighting the need for effective treatment strategies.
  • Current chemotherapy regimens for mTNBC have limited efficacy and no universally preferred standard.

Purpose of the Study:

  • To provide practical consensus recommendations for the treatment of metastatic triple-negative breast cancer (mTNBC).
  • To guide community oncologists on new chemotherapeutic strategies and agents for mTNBC management.
  • To consolidate expert opinion and literature data for improved mTNBC patient care.

Main Methods:

  • A consensus-building process involving expert oncologists.
  • Review of published literature on mTNBC treatment.
  • Incorporation of practical clinical experience and expert opinion.

Main Results:

  • Identification of emerging chemotherapeutic strategies for mTNBC.
  • Discussion of novel agents and their potential role in mTNBC treatment.
  • Development of practical recommendations for community oncologists.

Conclusions:

  • Effective management of mTNBC requires consideration of novel chemotherapeutic approaches.
  • Consensus recommendations aim to optimize treatment selection for patients with mTNBC.
  • Addressing treatment resistance and rapid relapse is crucial in mTNBC care.
Keywords:
AR testingBRCAgermline mutationpoly (adenosine diphosphate–ribose) polymerase 1 inhibitorsprogrammed cell death ligand 1rebiopsy

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