Related Experiment Video

Updated: Feb 11, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.5K

Resveratrol Prevents Diabetic Cardiomyopathy by Increasing Nrf2 Expression and Transcriptional Activity

Guan Wang1, Xianjin Song1, Lei Zhao1

  • 1Department of Cardiology, The Second Hospital of Jilin University, Jilin University, Changchun 100032, China.

Biomed Research International
|May 4, 2018
PubMed
Abstract

Insights

Resveratrol treatment improved cardiac function and reduced fibrosis in diabetic mice by targeting oxidative stress. This was achieved by increasing Nrf2 expression and activity, offering a potential therapeutic strategy for diabetic cardiomyopathy.

Area of Science:

  • Cardiovascular Research
  • Metabolic Disorders
  • Pharmacology

Background:

  • Diabetic cardiomyopathy is a significant complication of diabetes mellitus.
  • Oxidative stress plays a critical role in the pathogenesis of diabetic cardiomyopathy.
  • Resveratrol, a natural polyphenol, has demonstrated antioxidant properties.

Purpose of the Study:

  • To investigate the protective effects of resveratrol against diabetic cardiomyopathy in a mouse model.
  • To elucidate the underlying mechanisms, particularly the role of oxidative stress and Nrf2 signaling.

Main Methods:

  • Type 1 diabetes mellitus was induced in FVB mice using streptozotocin.
  • Mice were treated with resveratrol (10 mg/kg/day) for one month and monitored for six months.
  • Cardiac function, blood pressure, oxidative damage, and fibrosis were assessed using various techniques including histopathology, PCR, and Western blot.

Main Results:

  • Diabetic mice exhibited cardiac dysfunction, hypertrophy, high blood pressure, and increased oxidative damage.
  • Resveratrol treatment attenuated cardiac dysfunction, hypertrophy, and fibrosis in diabetic mice.
  • Resveratrol mitigated oxidative stress markers and increased Nrf2 expression and transcriptional activity.

Conclusions:

  • Resveratrol effectively prevents and ameliorates diabetic cardiomyopathy in mice.
  • The cardioprotective effects of resveratrol are partly mediated by enhancing Nrf2-dependent antioxidant pathways.
  • Resveratrol represents a promising therapeutic agent for diabetic cardiomyopathy.

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

657
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.111:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.5K

Related Concept Videos

Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
12.9K
Prokaryotic Transcriptional Activators and Repressors01:58

Prokaryotic Transcriptional Activators and Repressors

The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
25.6K
Prokaryotic Transcriptional Activators and Repressors01:58

Prokaryotic Transcriptional Activators and Repressors

10.6K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
588
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
524
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
583