Related Experiment Video

Updated: Feb 11, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K

Cardiovascular outcome in type 2 diabetes and atrial fibrillation

A Costard-Jäckle1, D Tschöpe1, T Meinertz2

  • 1Diabetes Center at Heart and Diabetes Center NRW, Ruhr University Bochum, Georg Str. 5, 32549, Bad Oeynhausen, Germany.

Herz
|May 4, 2018
PubMed

Insights

Diabetes significantly increases atrial fibrillation (AF) risk, especially with poor glycemic control. Managing diabetes and AF is crucial for reducing cardiovascular complications and mortality in affected patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Diabetes mellitus is a significant independent risk factor for atrial fibrillation (AF).
  • Metabolic syndrome, including obesity and hypertension, often coexists with diabetes and independently elevates AF risk.
  • Prolonged diabetes duration and inadequate glycemic control exacerbate the risk of developing AF.

Purpose of the Study:

  • To highlight the heightened risk of mortality and cardiovascular complications in patients with comorbid diabetes and AF.
  • To explore the potential benefits of good metabolic control on maintaining sinus rhythm post-AF treatment.
  • To emphasize the role of novel antidiabetic agents in managing AF risk in type 2 diabetes.

Main Methods:

  • Review of existing literature on the association between diabetes, metabolic syndrome, and atrial fibrillation.
  • Analysis of patient outcomes comparing those with diabetes and AF versus those in sinus rhythm.
  • Examination of the impact of glycemic control and specific antidiabetic medications on AF prognosis.

Main Results:

  • Patients with diabetes and AF face a substantially increased risk of death and severe cardiovascular events.
  • Effective metabolic control correlates with better rhythm maintenance after AF conversion therapies.
  • Newer antidiabetic drug classes, like incretin analogues and SGLT-2 inhibitors, show promise in mitigating AF-related risks in type 2 diabetes.

Conclusions:

  • A proactive diagnostic approach for AF in diabetic patients is essential, alongside routine diabetes monitoring.
  • Anticoagulation remains critical for preventing thromboembolic complications in this high-risk population.
  • Further research is needed to confirm the prognostic value of restoring sinus rhythm in diabetic patients with AF.

Keywords:
AnticoagulantsCardiac arrhythmiaCardiac resynchronization therapyDiabetes mellitus type IIThromboembolism

More Related Videos

Robotic Ablation of Atrial Fibrillation11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

20.2K
Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats05:12

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

3.8K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.0K
Amyloid Fibrils03:03

Amyloid Fibrils

6.5K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K