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Updated: Feb 11, 2026

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
Published on: December 8, 2023
Review of diagnostic, prognostic, and predictive biomarkers in melanoma
Jacob S Ankeny1, Brian Labadie2, Jason Luke2
1Department of Cutaneous Oncology, Moffitt Cancer Center, 10920 McKinley Dr., MKC 4th 11.4123, Tampa, FL, 33612, USA.
Abstract:
Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenges, multiple high throughput, nucleic-acid based biomarkers have been developed that can be assayed from histologic tissue specimens. FISH, CGH, Decision-Dx, and other multi-marker assays have been combined to improve overall predictability. This review discusses some of the most promising nucleic acid based assays that can be obtained from tissue specimens to assist with diagnosis, prognostication, and prediction of treatment response.
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