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Long-term abiraterone withdrawal syndrome.
Journal of Clinical Pharmacy and Therapeutics
|May 4, 2018
Summary
Abiraterone withdrawal syndrome (AWS) can occur even without stopping prednisone. This case study shows a patient experienced long-term AWS, delaying further prostate cancer treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Abiraterone acetate (AA) is an androgen receptor axis inhibitor used for metastatic castration-resistant prostate cancer (mCRPC).
- Abiraterone withdrawal syndrome (AWS) is less understood compared to withdrawal from traditional antiandrogens.
- AWS may be linked to concurrent prednisone cessation or the androgenic effects of AA metabolites.
Observation:
- A case of a patient experiencing prolonged AWS is presented.
- The patient did not discontinue prednisone concurrently with abiraterone acetate.
- Clinical and prostate-specific antigen (PSA) response facilitated an 8-month delay in initiating docetaxel.
Findings:
- Prednisone discontinuation was not a contributing factor to AWS in this specific case.
- The patient demonstrated a sustained response to abiraterone acetate, indicating its potential for long-term efficacy.
Implications:
- This case suggests that AWS can occur independently of prednisone use.
- Understanding AWS is crucial for managing patients with mCRPC on abiraterone acetate.
- The findings may inform treatment strategies and patient monitoring for abiraterone acetate therapy.
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