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Estimating pediatric general anesthesia exposure: Quantifying duration and risk

Devan Darby Bartels1, Mary Ellen McCann2, Andrew J Davidson3

  • 1Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Paediatric Anaesthesia
|May 4, 2018
PubMed

Insights

Most children receive less than 3 hours of pediatric general anesthesia. Infants under 1 year, those with high ASA status, and university hospital patients face longer anesthesia durations, informing future neurodevelopmental studies.

Area of Science:

  • Anesthesiology
  • Pediatric Medicine
  • Neurodevelopmental Research

Background:

  • Understanding pediatric general anesthesia duration is crucial for identifying risks and designing neurodevelopmental outcome studies.
  • Contemporary data on anesthesia exposure times in children are limited.

Purpose of the Study:

  • To estimate the duration of pediatric general anesthesia exposure.
  • To identify patient and hospital factors associated with prolonged anesthesia exposure.
  • To inform future research on neurodevelopmental outcomes related to anesthesia exposure.

Main Methods:

  • Retrospective cohort analysis of pediatric general anesthetics.
  • Data sourced from the National Anesthesia Clinical Outcomes Registry (NACOR) between 2010-2015.
  • Inclusion of 1,548,021 pediatric general anesthetics.

Main Results:

  • Median general anesthesia duration was 57 minutes (IQR: 28-86).
  • Children under 1 year experienced the longest median exposure (79 minutes, IQR: 39-119), with 13.7% exposed for over 3 hours.
  • Higher ASA physical status and university hospital care were linked to longer anesthesia durations.

Conclusions:

  • While 94% of pediatric patients have anesthesia exposure under 3 hours, specific groups are at higher risk for prolonged exposure.
  • Findings aid in designing future trials focusing on the neurodevelopmental impact of prolonged anesthesia in at-risk pediatric populations.
Abstract

Keywords:
adolescentchildgeneral anesthesiainfantneonateneurodevelopment

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