Collagen for brain repair: therapeutic perspectives

Area of Science:

• Biomaterials Science
• Neuroscience
• Regenerative Medicine

Background:

• Biomaterials are crucial for neuroprotection and neuroregeneration research.
• Collagen exhibits excellent biocompatibility, biodegradability, versatility, and non-toxicity for brain repair applications.

Purpose of the Study:

• To review collagen biomaterial applications in central nervous system (CNS) protection and repair.
• To highlight collagen's potential in treating neurodegenerative diseases and CNS injuries.

Main Methods:

• Review of existing literature on collagen-based biomaterials for CNS applications.
• Analysis of collagen's properties and its use in scaffolds and micro/nanospheres.

Main Results:

• Collagen facilitates local therapeutic factor release for neuroprotection.
• It enables safe encapsulation of stem and genetically modified cells for sustained factor delivery.
• Collagen serves as a structural support, filling voids and promoting axonal growth.

Conclusions:

• Collagen is a promising natural biomaterial for CNS protection and repair.
• Its diverse applications hold potential for advancing therapeutic strategies for CNS injuries and degeneration.