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Related Experiment Video

Updated: Feb 11, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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[Immunization and autoimmune neurological diseases].

Patrice H Lalive1,2

  • 1Unité de neuroimmunologie et des maladies neuromusculaires, Service de neurologie, Département des neurosciences cliniques, HUG, 1211 Genève 14.

Revue Medicale Suisse
|May 4, 2018
PubMed
Summary

Vaccinating patients with autoimmune neurological diseases is often safe, despite unfounded fears of immune system reactivation. Not vaccinating increases risks from preventable infections, especially for immunosuppressed individuals.

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Area of Science:

  • Neurology
  • Immunology
  • Vaccinology

Context:

  • Autoimmune neurological diseases encompass a wide range of conditions affecting the nervous system, neuromuscular junction, and muscles.
  • Concerns regarding vaccination in these patients often stem from unfounded fears of disease reactivation.
  • The risks associated with not vaccinating, including infection-induced exacerbation and increased infectious risk in immunosuppressed patients, are critical considerations.

Purpose:

  • To address the risks and benefits of vaccination in patients with autoimmune neurological diseases.
  • To evaluate the scientific basis of fears surrounding vaccine-induced immune reactivation.
  • To highlight the potential dangers of foregoing vaccination, particularly for vulnerable patient groups.

Summary:

  • Vaccination in autoimmune neurological diseases is frequently safe, contrary to common concerns about immune system stimulation.
  • The potential for infection-related disease worsening in unvaccinated individuals is a significant risk.
  • Immunosuppressed patients with autoimmune neurological diseases face heightened infectious risks if not vaccinated.

Impact:

  • Provides evidence-based guidance for clinicians and patients regarding vaccination decisions in autoimmune neurological diseases.
  • Aims to alleviate unfounded fears and promote informed choices about preventative healthcare.
  • Emphasizes the importance of considering the risks of non-vaccination in managing these complex conditions.