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Updated: Feb 11, 2026
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Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
Published on: August 16, 2014
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Microcapsule Technology for Controlled Growth Factor Release in Musculoskeletal Tissue Engineering
Giovanna Della Porta1, Maria C Ciardulli, Nicola Maffulli
1Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy.
Sports Medicine and Arthroscopy Review
|May 4, 2018
Summary
Engineered 3D scaffolds using bioplotting enable precise cell and growth factor delivery for stem cell differentiation. This technology creates interactive microenvironments for advanced tissue engineering applications.
Area of Science:
- Tissue Engineering
- Biomaterials Science
- Regenerative Medicine
Background:
- 3D scaffolds are crucial in tissue engineering to mimic native cell environments.
- Hydrogel molding and bioplotting offer methods for fabricating 3D scaffolds with controlled microstructures.
Purpose of the Study:
- To review technologies for fabricating 3D scaffolds for stem cell cultivation and differentiation.
- To discuss biopolymer micro/nanocarrier fabrication for controlled delivery of growth factors within these scaffolds.
Main Methods:
- Bioplotting of hydrogels with cells (bio-ink) and additives like growth factor-releasing micro/nanodevices.
- Spatial organization of cellular components and biomolecules within a 3D pattern using computer-aided design.
- Fabrication of biopolymer microcapsules for sustained controlled release over several days.
Main Results:
- Bioplotting allows precise spatial arrangement of cells and delivery systems within 3D hydrogel scaffolds.
- Biopolymer micro/nanodevices enable controlled spatiotemporal delivery of biosignals, enhancing stem cell interaction.
- Review of various microcapsule fabrication technologies for controlled release applications.
Conclusions:
- Engineered 3D hydrogel scaffolds with controlled growth factor delivery create interactive microenvironments for stem cell differentiation.
- Bioplotting and advanced micro/nanocarrier technologies are strategic for developing bioengineered tissues.
- Critical discussion of fabrication technologies supports future advancements in regenerative medicine.
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