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Updated: Feb 11, 2026

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
Published on: February 28, 2017
Amniotic Epithelial Stem Cells: Salient Features and Possible Therapeutic Role
Aurelio Muttini1, Barbara Barboni1, Luca Valbonetti1
1Faculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo.
Abstract:
This is a study of amniotic epithelial cells, which form the innermost layer of the amniotic membrane. These cells can be easily isolated and display peculiar and unique properties, such as plasticity and differentiation potential toward the 3 germinal layers, that may aid regeneration and/or repair of damaged or diseased tissues and organs. A robust literature based on in vitro, experimental, and clinical studies in large animals demonstrates that these cells can enhance the regeneration of tendons, bone, and articular cartilage. On the basis of these considerations, allotransplantation of human amniotic epithelial cells could be proposed for clinical trials in human orthopedic conditions.
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