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Updated: Feb 11, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans
Published on: June 25, 2013
[Gene regulation of prostaglandin synthase and prostate diseases]
Shuang-Shuang Wu1, Jian-Hui Wu1, Zu-Yue Sun1
1Department of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research / National Evaluation Center for Toxicology of Fertility Regulation Drugs, Shanghai 200032, China.
Abstract:
Prostaglandin synthase (PGS) can catalyze the production of various types of prostaglandins and regulate the expression levels of related substances. The regulation mechanisms of the PGS gene are closely related with the occurrence and development of prostate diseases. However, few studies are reported on the regulation mechanisms of PGS in prostatic diseases, such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa), or on the relationship between PGS gene regulation and prostate diseases. This review aims to analyze their correlation and provide some ideas for the prevention and control of BPH and PCa by intervention of the prostaglandin synthase regulatory pathway.
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