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Updated: Feb 11, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.2K

Cross-regulation between Notch signaling pathway and miRNA machinery in cancer

Maryam Majidinia1, Saber Ghazizadeh Darband2, Mojtaba Kaviani3

  • 1Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.

DNA Repair
|May 4, 2018
PubMed

Insights

MicroRNAs (miRNAs) and Notch signaling pathways collaboratively regulate cancer development. This review explores their intricate crosstalk, offering insights into novel cancer therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Notch signaling pathway is crucial for fundamental cellular processes like development and cell-fate determination.
  • Non-coding microRNAs (miRNAs) play a significant role in cancer by regulating oncogenes and tumor suppressor genes.
  • Emerging evidence highlights a complex interplay between miRNAs and Notch signaling in cancer.

Purpose of the Study:

  • To review the current understanding of the crosstalk between miRNAs and the Notch signaling pathway.
  • To discuss the implications of this interaction in various aspects of cancer progression and regression.
  • To identify potential therapeutic strategies based on this molecular interplay.

Main Methods:

  • Literature review of existing research on miRNA-Notch signaling interactions in cancer.
  • Analysis of studies investigating the role of this crosstalk in cancer stem cells, angiogenesis, metastasis, and drug resistance.

Main Results:

  • miRNAs and Notch signaling components exhibit a bidirectional regulatory relationship in cancer.
  • This crosstalk influences key cancer hallmarks including cancer stem cell maintenance, tumor angiogenesis, metastasis, and multidrug resistance.

Conclusions:

  • The intricate relationship between miRNAs and Notch signaling is a critical determinant of cancer fate.
  • Understanding this crosstalk provides a foundation for developing novel targeted cancer therapies.
Keywords:
Cancer progressionCancer therapySignaling pathwaymicroRNA

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