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Assessment of Motor Balance and Coordination in Mice using the Balance Beam
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Balancing forces in migration.

Patrick W Oakes1

  • 1Department of Physics & Astronomy, University of Rochester, Rochester, NY 14627, United States; Department of Biology, University of Rochester, Rochester, NY 14627, United States.

Current Opinion in Cell Biology
|May 4, 2018
PubMed
Summary

Cellular networks generate physical forces through protein interactions. The cytoskeleton

Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Integrated molecular interactions form active biological networks.
  • These networks influence physiological processes, notably force generation and response.
  • The cytoskeleton is crucial for cellular shape, physical interactions, and self-organization.

Purpose of the Study:

  • To review the current understanding of cytoskeleton material properties.
  • To explore how physical interactions with the extracellular environment affect cell migration.

Main Methods:

  • Literature review of biophysical and cell biology research.
  • Analysis of studies on cytoskeletal dynamics and extracellular matrix interactions.

Main Results:

  • Cytoskeleton's material properties are integral to cellular force generation.

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  • Cellular interactions with the extracellular environment are mediated by the cytoskeleton.
  • Cytoskeletal self-organization directly impacts cell migration dynamics.

    • Conclusions:

    • The cytoskeleton's mechanical properties are key to cell motility.
    • Understanding these properties is vital for cell migration research.
    • Further investigation into cytoskeleton-extracellular matrix interplay is warranted.