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Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis
Moussa Yabré1,2, Ludivine Ferey3, Issa Touridomon Somé4
1ChemBioPharm Team, ARNA Laboratory, INSERM U1212, CNRS UMR 5320, Bordeaux University, F-33000 Bordeaux, France. moussa.yabre@u-bordeaux.fr.
Greening analytical methods in pharmaceutical analysis is crucial. This review explores recent advances in greener reversed-phase high-performance liquid chromatography (RP-HPLC) using alternative solvents to reduce environmental impact.
Area of Science:
- Pharmaceutical Analysis
- Green Chemistry
- Analytical Chemistry
Background:
- Reversed-phase high-performance liquid chromatography (RP-HPLC) is vital in pharmaceutical analysis.
- Traditional RP-HPLC methods generate significant organic solvent waste, posing ecological and safety concerns.
- Greening analytical methods is increasingly important for sustainability and analyst safety.
Purpose of the Study:
- To review and critically discuss recent advancements in greening RP-HPLC methods for pharmaceutical analysis.
- To highlight the use of alternative solvents to reduce environmental impact.
- To explore strategies for more sustainable pharmaceutical analysis.
Main Methods:
- Review of recent literature on green RP-HPLC methods.
- Focus on alternative organic solvents (e.g., ethanol) and other green approaches.
- Critical discussion of method applicability and advancements.
Main Results:
- Ethanol is a common alternative solvent.
- Other strategies include totally aqueous mobile phases, micellar liquid chromatography, and ionic liquids.
- These green approaches are often economical and do not require new equipment.
Conclusions:
- Greener RP-HPLC methods are essential for sustainable pharmaceutical analysis.
- Alternative solvents and techniques offer viable solutions to reduce environmental impact.
- Continued development in green analytical chemistry is vital for the pharmaceutical industry.
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In HPLC, two phases play a critical role in the separation process:
High-Performance Liquid Chromatography: Instrumentation
Solvents
A...