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Updated: Feb 11, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Stendomycin and Pantomycin Are Identical Natural Products: Preparation of a Functionalized Bioactive Analogue
Nikolaj L Villadsen1, Bente K Hansen1, Esben B Svenningsen1
1Department of Chemistry , Aarhus University , 8000 Aarhus , Denmark.
Abstract:
The natural products pantomycin and stendomycin were both reported as antimicrobial agents. We demonstrate by gene cluster analysis, LC-MS analysis, and isolation that these polypeptides are identical, and we identify previously unknown congeners. We show that stendomycin can be chemically modified at its electrophilic dehydrobutyrine moiety yielding the first bioactive analogue of this natural product which can undergo additional functionalization. This compound may be a valuable starting point for molecular probe development, and we invite its distribution to the scientific community.
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