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    Ensuring safe anticancer drug preparation is crucial. Robotization and Drugcam® show the lowest risk for enhancing quality and security in hospital pharmacies.

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    Area of Science:

    • Pharmaceutical Sciences
    • Oncology Pharmacy Practice
    • Hospital Pharmacy Quality Control

    Background:

    • Rising cancer incidence necessitates increased anticancer drug preparation in hospitals.
    • Ensuring the quality and security of these preparations is vital for efficacy and minimizing patient toxicity.
    • Existing methods for preparation control (non-analytical and analytical) are varied, making selection challenging based on hospital priorities.

    Purpose of the Study:

    • To review existing methods for enhancing the security of anticancer drug preparation.
    • To analyze preparation and control steps using a proactive hazard analysis method.
    • To discuss method selection based on quality, security, and potential failure risks.

    Main Methods:

    • Review of various existing methods for anticancer drug preparation security.
    • Application of a proactive hazard analysis method to preparation and control steps.
    • Evaluation of methods based on criticality scores and potential failure risks.

    Main Results:

    • No single method is universally perfect for anticancer drug preparation.
    • Robotization demonstrated the lowest criticality score for overall preparation security.
    • Drugcam® was highly effective, particularly for re-labelling all containers, showing low risk.

    Conclusions:

    • Hospital pharmacies face challenges in selecting optimal methods for anticancer drug preparation.
    • Robotization and Drugcam® emerge as promising methods with lower risk profiles.
    • University Hospital Centres should consider these risk indexes when implementing control methods for enhanced safety.