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Coronary Artery Disease in Patients ≥80 Years of Age

Mahesh V Madhavan1, Bernard J Gersh2, Karen P Alexander3

  • 1New York-Presbyterian Hospital and the Columbia University Medical Center, New York, New York.

Journal of the American College of Cardiology
|May 5, 2018
PubMed

Insights

Older adults (≥80) with coronary artery disease (CAD) are understudied. This review highlights knowledge gaps and future research needs for better CAD management in this population.

Area of Science:

  • Cardiology
  • Geriatric Medicine
  • Clinical Trials

Background:

  • Coronary artery disease (CAD) significantly impacts morbidity and mortality in adults aged 80 and older.
  • Older adults are often underrepresented in cardiovascular clinical trials, limiting evidence-based treatment guidelines.
  • Optimizing the diagnosis and treatment of CAD in this demographic is critical for improving health outcomes.

Purpose of the Study:

  • To systematically review the current knowledge base regarding CAD in patients aged 80 and older.
  • To identify existing gaps in understanding the pathophysiology, epidemiology, diagnosis, and treatment of CAD in this population.
  • To outline directions for future research to advance CAD care for older adults.

Main Methods:

  • Systematic literature review.
  • Analysis of existing studies on coronary artery disease in elderly populations (≥80 years).
  • Synthesis of current knowledge and identification of research deficits.

Main Results:

  • Significant gaps exist in understanding CAD in patients aged 80+.
  • Current clinical trial data inadequately represents this high-risk group.
  • A patient-centered approach considering frailty and preferences is essential but under-researched.

Conclusions:

  • Further research is urgently needed to address the unique aspects of CAD in adults aged 80 and older.
  • Future studies should focus on pathophysiology, epidemiology, and tailored diagnostic and treatment strategies.
  • Improved evidence is crucial for enhancing the care and outcomes of elderly individuals with CAD.

Keywords:
coronary artery diseasegeriatric cardiologyoctogenarians

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