Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

D P Borges1, A W A Santos1, S M M Magalhaes2

  • 1Post-Graduate program in Medical Science, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Journal De Mycologie Medicale
|May 5, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and treatment of interstitial lung disease related to systemic autoimmune myopathies: a narrative review.

Reumatismo·2023
Same author

Role of Brazilian bats in the epidemiological cycle of potentially zoonotic pathogens.

Microbial pathogenesis·2023
Same author

Age, Blasts, Performance Status and Lenalidomide Therapy Influence the Outcome of Myelodysplastic Syndrome With Isolated Del(5q): A Study of 58 South American Patients.

Clinical lymphoma, myeloma & leukemia·2021
Same author

Ex situ model of biofilm-associated wounds: providing a host-like environment for the study of Staphylococcus aureus and Pseudomonas aeruginosa biofilms.

Journal of applied microbiology·2021
Same author

The global epidemiology of emerging <i>Histoplasma</i> species in recent years.

Studies in mycology·2020
Same author

Multicenter, International Study of MIC/MEC Distributions for Definition of Epidemiological Cutoff Values for Sporothrix Species Identified by Molecular Methods.

Antimicrobial agents and chemotherapy·2017

This case report details a rare Fusarium solani infection in a myelodysplastic syndrome patient, presenting as granulocytic sarcoma, an initial sign of acute myeloid leukemia transformation. Early skin lesion evaluation is crucial for immunocompromised individuals.

Area of Science:

  • Medical Mycology
  • Hematology
  • Oncology

Background:

  • Severely immunocompromised patients face risks of unusual infections with atypical presentations.
  • Fusarium species infections are documented in hematological malignancy patients, often with high mortality requiring prompt diagnosis.

Observation:

  • A case study of a myelodysplastic syndrome (MDS) patient is presented.
  • The patient exhibited Fusarium solani infection manifesting as a granulocytic sarcoma, which was the initial presentation of acute myeloid leukemia (AML) transformation.

Findings:

  • Histological examination, immunohistochemistry, tissue culture, and DNA sequencing confirmed Fusarium solani infection and granulocytic sarcoma.
  • The findings highlight an uncommon presentation of invasive fungal infection and malignancy progression.
Keywords:
Acute myeloid leukemiaFusarium solaniGranulocytic sarcomaMyelodysplastic syndrome

Related Experiment Videos

Implications:

  • Emphasizes the critical need for thorough evaluation of all skin lesions in immunocompromised patients.
  • Suggests that cutaneous manifestations can be early indicators of serious underlying conditions like AML transformation in MDS patients.
  • Underscores the importance of multidisciplinary diagnostic approaches for rare fungal infections in immunocompromised hosts.