Lighting a Fire in the Tumor Microenvironment Using Oncolytic Immunotherapy
Carole Achard1, Abera Surendran2, Marie-Eve Wedge3
1Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa K1H 8L6, Canada.
Ebiomedicine
|May 5, 2018
Summary
Oncolytic virus (OV) therapy offers a versatile approach to cancer treatment by reprogramming the tumor microenvironment (TME). OVs disrupt immunosuppressive TME factors, promoting potent and lasting anti-tumor immune responses for improved cancer immunotherapy.
Area of Science:
- Oncology
- Immunology
- Virology
Background:
- The tumor microenvironment (TME) significantly influences cancer prognosis and immunotherapy effectiveness.
- Oncolytic viruses (OVs) are emerging as a promising cancer treatment modality.
- OVs possess versatile, multi-modal tumor eradication capabilities.
Purpose of the Study:
- To review how oncolytic viruses (OVs) alter the tumor microenvironment (TME).
- To explore the strategic use of OVs in creating a pro-immune TME.
- To highlight the potential for enhanced host antitumor immune responses.
Main Methods:
- Literature review of studies on oncolytic virus therapy and TME modulation.
- Analysis of data on OV-induced changes in the immune landscape of tumors.
- Synthesis of information on combining OVs with immune modulators.
Main Results:
- Oncolytic viruses (OVs) can dramatically alter the immunosuppressive TME.
- OVs disrupt the TME, leading to improved antitumor activity.
- Strategic application of OVs can foster a pro-immune environment.
Conclusions:
- Oncolytic virus (OV) therapy holds significant potential for cancer immunotherapy.
- OVs can be strategically employed to overcome TME-mediated immunosuppression.
- This approach may lead to potent and durable host antitumor immune responses.
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