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Updated: Feb 11, 2026

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CSF Pressure Change in Relation to Opening Pressure and CSF Volume Removed.

B Griffith1, T Capobres2, S C Patel2

  • 1From the Departments of Radiology (B.G., T.C., S.C.P., H.M.) brentg@rad.hfh.edu.

AJNR. American Journal of Neuroradiology
|May 5, 2018
PubMed
Summary

Idiopathic intracranial hypertension shows increasing craniospinal elastance with higher opening pressures. This suggests altered cerebrospinal fluid dynamics may be linked to the condition's pathophysiology.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Cerebrospinal Fluid Dynamics

Background:

  • Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure.
  • The relationship between cerebrospinal fluid (CSF) pressure and volume is crucial for understanding IIH.
  • Investigating the craniospinal elastance and pressure-volume index in IIH patients is essential.

Purpose of the Study:

  • To determine the correlation between CSF pressure-volume relationship parameters (craniospinal elastance and pressure-volume index) and opening pressure in IIH patients.
  • To assess if opening pressure influences the CSF pressure-volume relationship in IIH.

Main Methods:

  • Analysis of lumbar puncture data from 116 patients diagnosed with or suspected of having IIH.
  • Calculation of craniospinal elastance and pressure-volume index from opening and closing pressures and CSF volume removed.
  • Statistical analysis using Pearson correlation and linear regression to evaluate associations with opening pressure and covariates.

Main Results:

  • A positive linear association was found between opening pressure and craniospinal elastance.
  • Craniospinal elastance increased by 0.28 cm H2O/mL for every 10 cm H2O increase in opening pressure (P < .001).
  • Age over 50 and total CSF volume removed were identified as covariates influencing this association.

Conclusions:

  • Craniospinal elastance increases linearly with rising opening pressure in IIH patients, while the pressure-volume index decreases.
  • These findings suggest potential alterations in CSF volume-pressure dynamics in IIH.
  • Further research is needed to clarify if these observed changes reflect IIH pathophysiology or general CSF dynamics.