Related Experiment Video
Updated: Feb 11, 2026
04:43
Detection of Lung Tumor Progression in Mice by Ultrasound Imaging
Published on: February 27, 2020
7.4K
AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Jun Won Park1,2, Il Yong Kim1,2, Ji Won Choi1
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Molecular Cancer Research : MCR
|May 5, 2018
Summary
AHNAK acts as a tumor suppressor in lung cancer by inhibiting epithelial cell growth and reducing pro-tumorigenic M2 macrophages. Its deficiency promotes lung tumorigenesis, highlighting its potential as a therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- AHNAK is a known tumor suppressor in breast cancer, activating TGFβ signaling.
- The role of AHNAK in lung cancer development and progression is currently unknown.
Purpose of the Study:
- To investigate the role of AHNAK in lung tumorigenesis.
- To elucidate the mechanisms by which AHNAK influences lung tumor development.
Main Methods:
- Gene disruption of Ahnak in mice.
- Analysis of lung tissue morphology and tumor incidence.
- Investigation of TGFβ signaling pathway and macrophage populations.
Main Results:
- AHNAK expression is decreased in human lung adenocarcinomas.
- Ahnak-deficient mice exhibit increased lung volume, hyperplasia, and spontaneous tumor development.
- Ahnak deficiency suppresses TGFβ signaling, promoting epithelial cell growth and M2 macrophage activation.
Conclusions:
- AHNAK functions as a novel tumor suppressor in lung cancer.
- AHNAK suppresses type II pneumocyte proliferation and inhibits M2 macrophage activation.
- AHNAK modulates the lung microenvironment to inhibit tumorigenesis.
More Related Videos
Related Concept Videos
01:12Loss of Tumor Suppressor Gene Functions
6.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K
01:10Line Loss
545
The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
545
02:40The Eukaryotic Promoter Region
18.9K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.9K
01:18Reducing Line Loss
392
In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
392
01:47Lung Capacity
56.4K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
01:28Major Losses in Pipes
2.0K
When a fluid flows through a pipe, it experiences energy losses due to frictional resistance along the pipe walls, known as major losses. These energy losses result in a pressure drop, which varies based on the flow conditions — whether laminar or turbulent — and the specific physical properties of the fluid and pipe.
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
2.0K