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Related Experiment Videos

Patch testing with a mixture of 2 phenol-formaldehyde resins.

M Bruze1

  • 1Department of Occupational Dermatology, University Hospital, Lund, Sweden.

Contact Dermatitis
|August 1, 1988
PubMed
Summary

Routine patch testing for phenol-formaldehyde resin allergy is improved by adding a resol resin (P-F-R-2) alongside the paratertiary-butylphenol-formaldehyde resin (PTBP-F-R). This approach significantly increases the diagnosis of contact allergies to these common resins.

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Area of Science:

  • Dermatology
  • Allergology
  • Chemical Sensitization

Background:

  • Phenol-formaldehyde resins are common allergens.
  • Current patch testing protocols may miss some cases of contact allergy.

Purpose of the Study:

  • To evaluate the efficacy of adding a resol resin (P-F-R-2) to routine patch testing for phenol-formaldehyde resin (PTBP-F-R) allergy.
  • To compare the diagnostic yield of separate versus mixed resin patch testing.

Main Methods:

  • Routinely patch tested 1310 patients with paratertiary-butylphenol-formaldehyde resin (PTBP-F-R), a resol resin (P-F-R-2), and a mixture of both.
  • Analyzed the number of diagnosed contact allergies to phenol-formaldehyde resins.

Main Results:

  • Adding P-F-R-2 to PTBP-F-R patch testing diagnosed 2.5 times more patients with contact allergy.

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  • Testing with a mixture of both resins diagnosed 1.6 times more patients than PTBP-F-R alone, but was less effective than separate testing.

    • Conclusions:

    • Resol resin (P-F-R-2) is recommended for routine patch testing to improve phenol-formaldehyde resin allergy diagnosis.
    • P-F-R-2 should preferably be used as a separate test, but a mixture with PTBP-F-R is a viable alternative.