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Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical

Hyeon Seok Hwang1, Jung Sun Cho2, Yu Ah Hong1

  • 1Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea.

International Journal of Medical Sciences
|May 5, 2018
PubMed

Insights

Vascular calcification (VC) and left ventricular hypertrophy (LVH) together significantly increase cardiovascular event risk in hemodialysis patients, showing a synergistic effect on mortality and events.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Vascular calcification (VC) and left ventricular hypertrophy (LVH) are common in hemodialysis (HD) patients.
  • The combined impact of VC and LVH on adverse outcomes in HD patients requires further investigation.

Purpose of the Study:

  • To examine the relationship between VC and LVH.
  • To evaluate the combined effect of VC and LVH on deaths and cardiovascular events (CVEs) in maintenance HD patients.

Main Methods:

  • 341 maintenance HD patients were analyzed.
  • Echocardiography and plain chest radiographs were used to assess LVH and aortic arch VC.
  • Multivariate analysis was performed to determine independent associations and interactions.

Main Results:

  • VC was present in 29.3% of patients and independently associated with a 2.42-fold increased risk of LVH.
  • The coexistence of VC and LVH was independently associated with CVEs (HR, 2.01) and composite deaths or CVEs (HR, 1.88).
  • VC or LVH alone did not independently associate with CVEs, but showed significant synergistic interaction for composite events (P=0.039).

Conclusions:

  • VC is independently associated with LVH in HD patients.
  • The combination of VC and LVH poses a higher risk for deaths and CVEs compared to either condition alone.
  • VC and LVH exhibit a synergistic interaction, amplifying the risk of adverse cardiovascular outcomes in HD patients.

Keywords:
cardiovascular eventdeathhemodialysisleft ventricular hypertrophyvascular calcification

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