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MicroRNAs associated with therapy of non-small cell lung cancer

Junmi Lu1, Yuting Zhan1, Juan Feng1

  • 1Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

International Journal of Biological Sciences
|May 5, 2018
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are key regulators in non-small cell lung cancer (NSCLC) development and drug resistance. This review explores how miRNAs impact NSCLC treatment efficacy, offering insights for novel therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) incidence is increasing, with poor prognosis often linked to drug resistance.
  • Current diagnostic and therapeutic approaches for NSCLC face limitations due to resistance.
  • Novel diagnostic and treatment strategies are urgently needed for NSCLC patients.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in non-small cell lung cancer (NSCLC) pathogenesis.
  • To investigate the correlation between miRNAs and the response to anticancer treatments in NSCLC.
  • To summarize recent findings on miRNAs and their impact on therapy availability in NSCLC.

Main Methods:

  • Comprehensive literature review of existing research.
  • Analysis of studies correlating miRNA expression with NSCLC progression.
  • Examination of research on miRNA targeting and drug response in NSCLC.

Main Results:

  • MicroRNAs (miRNAs) are implicated in key cancer processes including proliferation, apoptosis, and tumorigenesis.
  • Specific miRNAs have been identified as potential regulators of drug resistance in NSCLC.
  • Findings suggest miRNAs can influence the effectiveness of various NSCLC therapies.

Conclusions:

  • MicroRNAs represent a promising area for developing precise diagnostic markers and effective therapeutic targets in NSCLC.
  • Understanding miRNA-mediated mechanisms can lead to improved treatment strategies for NSCLC.
  • Further research into miRNAs holds potential for overcoming drug resistance and improving patient outcomes in NSCLC.
Keywords:
NSCLCmicroRNAsradio-chemotherapytargeted therapy

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