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Downregulation of BRAF-activated non-protein coding RNA in patients with hepatitis B virus-associated hepatocellular

Na-Na Zhao1, Cheng Wang2, Cheng-Cai Lai3

  • 1Department of Hepatobiliary Surgery, Beijing 302 Hospital, Beijing 100039, P.R. China.

Oncology Letters
|May 5, 2018
PubMed

Insights

Long non-coding RNA BANCR (BRAF-activated non-protein coding RNA) is downregulated in hepatitis B virus-associated hepatocellular carcinoma. This finding suggests BANCR may serve as a diagnostic and therapeutic biomarker for liver cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are emerging regulators of cellular functions, including cancer development.
  • The lncRNA BRAF-activated non-protein coding RNA (BANCR) is implicated in various cancers but its role in hepatocellular carcinoma (HCC) remains uninvestigated.

Purpose of the Study:

  • To investigate the expression profile of lncRNA BANCR in hepatitis B virus-associated HCC.
  • To analyze the correlation between BANCR expression and clinicopathological features in HCC patients.

Main Methods:

  • Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to measure BANCR expression levels in tumor and adjacent non-tumor tissues.
  • Statistical analysis was performed to associate BANCR expression with clinicopathological characteristics.

Main Results:

  • BANCR expression was significantly downregulated in HCC tumor tissues compared to para-cancerous tissues (P<0.001).
  • Reduced BANCR expression correlated with elevated serum α-fetoprotein levels (P<0.01) and increased tumor number (P<0.05).

Conclusions:

  • This study is the first to report the downregulation of BANCR in HBV-associated HCC.
  • lncRNA BANCR may serve as a potential diagnostic and therapeutic biomarker for HCC.
Keywords:
BRAF-activated non-protein coding RNAhepatocellular carcinomareverse transcription-quantitative polymerase chain reaction

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