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Updated: Feb 11, 2026
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
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Increased KIF4A expression is a potential prognostic factor in prostate cancer.
Hongwei Gao1, Xuanrong Chen1, Qiliang Cai1
1Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China.
Oncology Letters
|May 5, 2018
Summary
Kinesin family protein 4A (KIF4A) is upregulated in prostate cancer (PCa), especially in advanced stages and castration-resistant tumors. Increased KIF4A expression correlates with poorer survival and predicts unfavorable outcomes in PCa patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Kinesin family protein 4A (KIF4A) is implicated in various human cancers, but its role in prostate cancer (PCa) remains understudied.
- KIF4A overexpression is linked to poor clinical prognosis in several cancer types.
Purpose of the Study:
- To investigate the clinical significance and prognostic value of KIF4A in prostate cancer.
- To analyze KIF4A expression patterns in PCa tissues and correlate them with clinical outcomes.
Main Methods:
- Utilized dataset analyses to assess KIF4A gene expression in prostate cancer patient cohorts.
- Performed univariate and multivariate analyses to evaluate the association between KIF4A expression and patient survival, including overall survival and biochemical recurrence-free survival.
Main Results:
- KIF4A expression was significantly elevated in castration-resistant PCa patients compared to other stages.
- KIF4A was highly expressed in PCa tissues versus non-cancerous tissues, particularly in advanced pathological stages.
- Upregulated KIF4A mRNA expression strongly correlated with shorter overall survival, prostate-specific antigen failure, and predicted poor biochemical recurrence-free survival.
Conclusions:
- KIF4A plays a crucial role in the progression of prostate cancer.
- Elevated KIF4A expression serves as a potential predictive biomarker for poor prognosis and biochemical recurrence in PCa patients.
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