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Mean platelet volume is associated with serum 25-hydroxyvitamin D concentrations in patients with stable coronary

Ilona Korzonek-Szlacheta1, Bartosz Hudzik2,3, Justyna Nowak1

  • 1Department of Nutrition-Related Disease Prevention, School of Public Health, Medical University of Silesia, Bytom, Poland.

Heart and Vessels
|May 5, 2018
PubMed

Insights

Low vitamin D levels are linked to larger platelet size in patients with coronary artery disease. This suggests a connection between vitamin D deficiency, platelet function, and cardiovascular risk.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Hematology

Background:

  • Limited data exists on the relationship between vitamin D concentration and platelet function.
  • Platelet volume is an indicator of platelet activation and reactivity.
  • Vitamin D deficiency is prevalent and associated with adverse cardiovascular outcomes.

Purpose of the Study:

  • To investigate the association between 25-hydroxyvitamin D (25(OH)D) concentration and mean platelet volume (MPV) in patients with stable coronary artery disease.
  • To explore the potential role of vitamin D in platelet function and hemostasis within this patient population.

Main Methods:

  • Cross-sectional study of patients with stable coronary artery disease.
  • Population stratified into three groups based on 25(OH)D levels: <10 ng/mL, 10-20 ng/mL, and >20 ng/mL.
  • Statistical analysis including correlation and ROC analysis to assess the relationship between MPV and 25(OH)D.

Main Results:

  • MPV was significantly higher in patients with lower 25(OH)D concentrations (P < 0.001).
  • A significant negative correlation was observed between MPV and 25(OH)D levels (R = -0.38, P = 0.001).
  • ROC analysis indicated moderate predictive value for MPV in identifying vitamin D deficiency.

Conclusions:

  • This study provides evidence linking lower vitamin D levels with increased platelet size in coronary artery disease patients.
  • Vitamin D deficiency may influence platelet function, potentially contributing to thrombosis and adverse cardiovascular events.
  • Platelets represent a potential mechanism through which vitamin D deficiency impacts cardiovascular health.

Keywords:
25(OH)DCoronary artery diseaseMean platelet volumeVitamin D

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